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KMID : 0358319960370101075
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Korean Journal of Urology
1996 Volume.37 No. 10 p.1075 ~ p.1079
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Effects of Electrical Field Simulation of the Isolated Corpus Cavernosum from Hypertensive Rats
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Abstract
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The present study was amined to investigate whether and to what extent hypertension affects the relaxation of the corpus cavernosum. The corpus cavernosum was isolated from 12-week-2-kindney, 1-clip hypertensive rats. The corporal strips were
isolated
and suspended longitudinally in an organ bath. They were precontrated with phenylephrine, and their responses to electrical field stimulation (EFS) were examined.
EFS caused a frequency-dependent contraction (60%) or relaxation (40%) of the corpus cavernosum precontracted wit phenylephrine. The contraction response was inhibited or abolished and only frequency-dependent relaxation appeared in the presence
of
atropine (10E-5 mol/L) and guanethidine (10E-5 mol/L). The relaxation response to EFS of the corporal preparation precontracted with phenylephine was attenuated or abolished in the presence of L-NAME (10E-4 mol/L). The corporal preparation from
the
hypertensive rats also showed a frequency of stimulation than that from the normotensive control.
These results suggest that endothelium-derived nitric oxide released upon neural stimulation partly mediate the relaxation of the corpus cavernosum. It is also suggested that hypertension is associated with a partly attenuated relaxation response
to
EFS.
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